Light-responsive RNA delivery
نویسندگان
چکیده
近年、mRNAやsiRNAなどの核酸医薬が、次世代の医療を支える医薬として期待を集めている。RNAを医薬として疾患部位で作用させるためには、標的細胞の細胞内への効率的なRNA送達法が重要となる。本稿では、さまざまなターゲティング戦略の中の1つである、光を用いた標的特異的RNA送達に注目する。具体的には、光化学的内在化(PCI)機構やPhotothermal機構を介して細胞質内にRNAを送達するキャリアを用いる方法について紹介する。これらのキャリアは、光で狙いうちした標的細胞のみにおいて細胞質内へのRNA送達を促進することで、標的特異的にRNA医薬を作用させることを可能にする。
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ژورنال
عنوان ژورنال: Drug Delivery System
سال: 2022
ISSN: ['0913-5006', '1881-2732']
DOI: https://doi.org/10.2745/dds.37.229